Tag: 新419站长推荐上海龙凤

Clutch Enables Your Motors to Achieve 100% Efficiency

first_imgThose little ATP synthase motors (see 01/30/2005 entry) in your body and (in all living cells) made news again in Nature1 last week.  Scientists in Tokyo performed an ingenious set of experiments to measure the efficiency of the F1 synthesizing domain.  They attached a tiny magnet to the camshaft so that they could turn it with electromagnets at will, and they carefully measured the amount of ATP synthesized or hydrolyzed as the motor turned anticlockwise or clockwise under their control.  In the hydrolysis cycle, they found that the motor did not waste ATP; each molecule was successfully hydrolyzed with perfect efficiency, to the limits of their detection.    A particular focus of their investigation was the role of the eta subunit, which is attached to the gamma camshaft.  During hydrolysis, the “downhill” function, it did not seem to matter whether eta was present or absent.  But in the “uphill” process (synthesizing ATP), it made a dramatic difference.  Without eta, each rotation produced, on average, only one product, but with it, they got three per revolution, with at least 77% efficiency.  The actual efficiency was probably higher, but was hard to measure for such small entities.  In best cases, it was 100%, they said: “Therefore our data point to an excellent mechanochemical coupling efficiency.  In the best cases, we observed the postulated value of three ATPs synthesized per turn.”    “These results are consistent with the ubiquity of this strategic enzyme that fuels most of the energy consuming biological processes,” they said (emphasis added in all quotes).  “The present work reveals the unexpected importance of the eta-subunit in the synthesis of ATP.”  Though its precise function remains to be discovered, it was known to play a regulatory role; now, this team suspects it acts like a structural switch or clutch to lock the enzyme into synthesis mode.  Without it, the tiny motor undergoes wasteful slippage.As a reminder to recent readers, you can find a wonderful animation of this molecular machine on the website of German biochemist Wolfgang Junge.  It is labeled “F0F1-ATPSynthase (animation)”  See also his Model Schematic.1Rondelez et al., “Highly coupled ATP synthesis by F1-ATPase single molecules,” Nature 433, 773 – 777 (17 February 2005); doi:10.1038/nature03277.By now, you expect our next observation: “The authors made no reference to evolution in their paper.”  They are treating these devices as actual mechanical motors, with stator, rotor, camshaft, and purposeful function, achieving performance stats beyond the dreams of human engineering.  Eat your heart out, David Hume.(Visited 9 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Virgin Hair Fertilizer Fast Hair Growth Treatment **pack of 3**, Excellent Recommend This!

first_imgThe seller need to be unique about the weight and written content of specific item. If this isn’t three packs of the 150g tubes, i will be sending it back. The description states the packed pounds all collectively is 299g, i would suppose it really should be 450g. Update alright, so my package deal arrived in the write-up and i was satisfied to see that it truly is 3 of the 150g tubes. It smells and feels like the authentic. I am expanding from one star to 4 stars. I only guidance that the seller should really be specified so that consumers are mindful. It can be a excellent discount for three.Have noticed slight variance, will keep on to use for a incredibly extended time.Key specs for Virgin Hair Fertilizer Fast Hair Growth Treatment **pack of 3**:VIRGIN HAIR FERTILIZER Anti Dandruff & Conditioning CreamFor Rapid Hair GrowthComments from buyers“This product is amazing. my hair has grown so well, Love this product, Excellent Recommend This!”The seller need to be unique about the weight and written content of specific item. If this isn’t three packs of the 150g tubes, i will be sending it back. The description states the packed pounds all collectively is 299g, i would suppose it really should be 450g. Update alright, so my package deal arrived in the write-up and i was satisfied to see that it truly is 3 of the 150g tubes. It smells and feels like the authentic. I am expanding from one star to 4 stars. I only guidance that the seller should really be specified so that consumers are mindful. It can be a excellent discount for three.Great product or service arrived on time – i would unquestionably purchase this once more.But i’ll preserve yall a update but it feels superior on my hair and it feels like its functioning. I didn’t see any benefits still but i will retain yall a update but it feels good on my hair and it feels like its doing the job gradually.But i’ll preserve yall a update but it feels superior on my hair and it feels like its functioning. I didn’t see any benefits still but i will retain yall a update but it feels good on my hair and it feels like its doing the job gradually.Great product or service arrived on time – i would unquestionably purchase this once more.I did not want the ‘new improved’ components. I preferred the first, and thus this solution was not as described.Incredibly week offer wait for more update. I’m supplying five* mainly because the parcel arrived extremely rapidly and quite effectively. I am gone give it much more time to produce a greater evaluate about the item mainly because is my initially time utilized it. Appropriate now i am making use of the products each individual night prior to heading to mattress will wait at checklist a month to publish advancement and give off program a greater opinion. Any approaches i gave one to my sister in legislation who endure from hair misplaced as i consider she requires it much more than myself.Have noticed slight variance, will keep on to use for a incredibly extended time.This stuff is effective great for me. This merchandise is doing the job wonders for my hair, i purchased it following looking at a extended-time period critique on you tube. I have been massaging it into my scalp just about every second working day and have seen an raise in growth and thickness in just 4 months. I chopped all my hair off in february 2015 & the growth has been really sluggish, until eventually i attempted this merchandise. I also had thinning edges and they are sprouting new hair hense the five* evaluate. It leaves a cooling, tingling feeling on my scalp and smells of peppermint. I gave a person tube to a pal who has stress induced alopecia and she has new hair sprouting way too. I will proceed employing it for a couple far more months and increase to my assessment then.Extraordinary for dry scalp support and selling hair growth. I use on both soaked and dry hair and couldn’t inquire for a superior product. Shipping was fast and the merchandise arrived in excellent problem as well.Bought it ages in the past and have only begun working with it. Every single weekend i leave on for a complete day (or as extensive as probable). My hair feels delicate, is dandruff free of charge and feels healthier.Employed with biotin very well support your hair improve.Extraordinary for dry scalp support and selling hair growth. I use on both soaked and dry hair and couldn’t inquire for a superior product. Shipping was fast and the merchandise arrived in excellent problem as well.I did not want the ‘new improved’ components. I preferred the first, and thus this solution was not as described.Incredibly week offer wait for more update. I’m supplying five* mainly because the parcel arrived extremely rapidly and quite effectively. I am gone give it much more time to produce a greater evaluate about the item mainly because is my initially time utilized it. Appropriate now i am making use of the products each individual night prior to heading to mattress will wait at checklist a month to publish advancement and give off program a greater opinion. Any approaches i gave one to my sister in legislation who endure from hair misplaced as i consider she requires it much more than myself.The best hair treatment hair fertiliser ????????.Its excellent i like the tingly sensation but i detest the delivery cost it expenditures alot.Employed with biotin very well support your hair improve.SummaryReviewer Nathalie DuboisReview Date2017-09-28 03:02:43Reviewed Item Virgin Hair Fertilizer Fast Hair Growth Treatment **pack of 3**Rating 5.0 / 5  stars, based on  0  reviewsPrice£9.52last_img read more

Palm Pre’s New Strategy: Forget iTunes, Hello Wireless Amazon Downloads

first_img5 Outdoor Activities for Beating Office Burnout sarah perez 4 Keys to a Kid-Safe App Related Posts 9 Books That Make Perfect Gifts for Industry Ex…center_img When the Palm Pre debuted, one of its most useful features was its ability to sync with Apple’s iTunes software. Unfortunately, how it went about doing this was a little bit underhanded: it pretended to be an iPhone. The most recent version of the hack – yes, there were several – was made possible by Palm’s use of Apple’s USB hardware vendor code provided by the USB Implementers Forum, an industry standards group. The Pre simply used Apple’s code so that iTunes would see the Pre as an Apple device. Apple of course, was not happy, and purposefully broke this functionality in subsequent iTunes software updates. Palm responded by complaining to the Forum, but the group took Apple’s side. Now, finally, the Apple/Palm war seems to have ended. With the latest update to Palm Pre’s webOS software, the company has come up with a new tactic altogether: forget about iTunes, use Amazon instead. Palm vs. AppleThe back-and-forth between Apple and Palm was getting ugly. A cat and mouse game transpired involving hacks, crippling updates from Apple, and then re-hacks from Palm which did nothing for either company’s image. Some felt that Apple had every right to protect their software from being used with other devices – after all, if something went wrong with Pre syncing, consumers could easily blame Apple’s software for the troubles. They may even call in for support, not understanding that Apple wouldn’t be able to handle issues arising from the use of a competitor’s hardware. Others, however, felt that Apple should open up. With their dominance over the entire digital media player industry, keeping their proprietary software a closed system was a way to make sure that no up-and-comers could ever have a shot at becoming a popular alternative to the iPod or iPhone. Palm, of course, felt this way, too. They complained to the USB-IF saying that consumers should have a right to decide how they use the media they purchase. That is, if they bought content from iTunes, they should be able to sync it to the Pre. The USB-IF did not agree, though. They sent letters to both companies explaining that Palm’s use of Apple’s USB vendor code actually violated the group’s rules and would need to end. Clearly, Palm lost this round, too – but don’t count them out just yet.Palm Releases webOS 1.2Yesterday, Palm released an update of the Pre software, webOS. While most of the reporting surrounding the new OS involved the important update which brings paid applications to the Pre’s App Catalog, another under-reported feature is actually just as (if not more) important. The Pre now lets you download over-the-air from Amazon’s MP3 Store.According to the Official Palm Blog, the Amazon integration now works over both WAN or Wi-Fi, meaning that you don’t need to be hooked up to a PC via USB to purchase music on your Pre. You can do so directly from the device, just like Apple iPod Touch and iPhone users can do through Apple’s mobile iTunes Store. Although the iTunes experience overall may have been the preferable option for many users, Amazon at least provides a viable alternative for Pre owners. Amazon’s online catalog may still be a few million short of that of Apple’s, but often their prices are much more affordable thanks to daily deals and albums that start at $4.99. While Palm hasn’t officially responded to the USB-IF’s letter – despite being told they had to do so within a week – it seems that they have, without actually saying so, made their decision. The latest update’s release notes do not mention iTunes syncing, and, as many expected, it has not been re-enabled. It looks like Palm Pre has given up the fight for good, now betting entirely on Amazon. The company’s original plan to sync with iTunes was a calculated risk and one which now leaves consumers holding the short end of the stick. How many Pre owners bought the Pre because it synced with iTunes? How many are angry or disappointed because it doesn’t now? It may have been better if Palm never went this route to begin with and worked on making the Amazon integration the key selling point from day one. Of course, hindsight is always 20/20. However, their decision may end up having a major impact on the company’s future, considering they’ve essentially bet the farm on webOS, ending support for devices running both the original Palm OS and Windows Mobile. Will giving up on iTunes impact device sales for the struggling company? Or will extricating themselves from this nasty war with Apple end up being the best thing they could have done? 12 Unique Gifts for the Hard-to-Shop-for People… Tags:#mobile#music#news#NYT#web last_img read more

Nikola Jokic continues to amaze as Nuggets rout Clippers

first_imgLATEST STORIES SEA Games: Biñan football stadium stands out in preparedness, completion Don’t miss out on the latest news and information. “He could play for NFL teams the way he passes the ball,” Malone said.Later, Jokic picked up his dribble on a play, saw the path through the lane was clear, banked it off the glass to himself and put it in. It was something he had never tried in a game before.And no, he wasn’t thinking slam.“I knew he wasn’t going to dunk it,” Murray cracked. “It was a smart move. It was a great play.”This capped off the night: Jokic and Miller exchanging jerseys.ADVERTISEMENT Nuggets: At Phoenix on Saturday before hosting Portland the following night.Sports Related Videospowered by AdSparcRead Next “It means a lot. I watched him a lot,” Jokic said. “He’s a beast. He’s someone that can’t be stopped.”These days, the same can be said of Jokic, who was coming off a game in Miami on Tuesday in which he had 29 points, 11 rebounds and 10 assists.“He’s just a great player,” Clippers coach Doc Rivers said.Murray scored 23 points and Mason Plumlee added a season-high 17 points to go with 12 rebounds for the Nuggets. They’re now 17-3 at home.Lou Williams led the Clippers with 19 points, and Danilo Gallinari chipped in 18 against his former team.Denver built the lead to 102-81 with 9:03 remaining on a jumper by Monte Morris. The Clippers made a little run, but Morris silenced it with a 3-pointer.“They just kicked our butt from the beginning,” said Tobias Harris, who finished with 18 points and 11 rebounds. “Their intensity and pace, we were kind of on our heels with all night. We’ve got to respect that especially from a team that’s No. 1 in the West.”Gallinari received applause from the crowd when he was announced. He joined the Clippers last season after a bulk of his career in Denver. He was limited to 21 games with Los Angeles in 2017-18 due to injuries and didn’t suit up when the Clippers played in the Mile High City.“It was a good feeling to see a lot of my friend and people that I know,” Gallinari said. “But honestly I was just focused on the game plan and trying to play my game and trying to help the team.”TIP-INS Behind LaMarcus Aldridge’s career-best 56, Spurs outlast Thunder in 2OT Hotel management clarifies SEAG footballers’ kikiam breakfast issue Private companies step in to help SEA Games hosting Another eventful evening for Jokic.The player nicknamed Joker finished with 18 points, 14 rebounds and 10 assists for his 21st career triple-double to help the Western Conference-leading Nuggets extend their home winning streak to 11 by cruising past the Los Angeles Clippers 121-100 on Thursday night.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine ‍football chiefSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool stars“Another triple-double,” Nuggets coach Michael Malone said. “The guy continues to amaze.”Jokic did a little bit of everything, including the pass of the night when he lofted a full-length strike over a defender to Jamal Murray for a dunk in the third quarter. TS Kammuri to enter PAR possibly a day after SEA Games openingcenter_img LOOK: Joyce Pring goes public with engagement to Juancho Triviño Clippers: F Luc Mbah a Moute remains out with a sore left knee.Nuggets: G Gary Harris missed his second straight game with tightness in his left hamstring. … F Juancho Hernangomez has been dealing with an injury. Earlier this season, he dealt with an abdominal strain. “If it gets to a point we have to shut him down for a bit, we’ll do so,” Malone said.EJECTEDClippers guard Patrick Beverley was ejected in the fourth quarter for arguing.Asked what he may have said, Rivers responded: “I was in the huddle. I think he said I love you.”NATIONAL TREASURESJokic, who’s from Serbia, currently sits in seventh place among Western Conference frontcourt players in the All-Star voting by fans. Dallas rookie and Slovenian native Luka Doncic is second, with fans counting for 50 percent of the vote to determine the starters.“Obviously, a lot of fans in Slovenia are voting and not enough fans in Serbia are voting,” Malone cracked.UP NEXTClippers: Begin a four-game homestand Saturday against Detroit. SEA Games: Biñan football stadium stands out in preparedness, completion Is Luis Manzano planning to propose to Jessy Mendiola? MOST READ PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss SEA Games hosting troubles anger Duterte Denver Broncos linebacker Von Miller and Denver Nuggets center Nikola Jokic swap jerseys following the Nuggets’ NBA basketball game against the Los Angeles Clippers on Thursday, Jan. 10, 2019, in Denver. Denver beat Los Angeles 121-100. (AP Photo/Jack Dempsey)DENVER  — Nikola Jokic wowed his teammates with a perfect full-court pass that led to a dunk and by tossing a pass to himself off the backboard for a layup.The Denver Nuggets big man was the one wide-eyed after the game when he met Broncos pass rusher Von Miller and exchanged jerseys.ADVERTISEMENT View commentslast_img read more

Man United target Goretzka injured again

first_imgSchalke 04 Man Utd & Arsenal target Goretzka to undergo tests on recurring leg injury Jamie Smith 02:01 12/7/17 FacebookTwitterRedditcopy Comments(0) Leon Goretzka Getty Images Schalke 04 Bundesliga Bundesliga high-flyers Schalke have confirmed their star midfielder has been ruled out again amid links with the Premier League Leon Goretzka is set for another spell on the sidelines after Bundesliga surprise package Schalke confirmed the midfielder will undergo tests on a leg injury.Goretzka, a reported target for Bayern Munich, Juventus and Barcelona, has featured twice for Domenico Tedesco’s side after recovering from a stress fracture sustained last month.But the Germany international, who starred in his country’s victory at the Confederations Cup, has been ruled out for the forseeable future. Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player “Leon Goretzka has suffered a recurrence of the injury in his lower leg,” Schalke said on Wednesday. “In order to put these continuous and worsening pains to bed, Leon will undergo examinations over the coming days.”Until then, it is unclear as to when Leon will be fit to train and play once again. Get well soon, Leon!”Get well soon, Leon!  #s04 pic.twitter.com/AtSPPlywee— FC Schalke 04 (@s04_en) December 6, 2017Schalke sit third in the Bundesliga having gone eight games unbeaten under 32-year-old Tedesco, but they are seven points adrift of holders Bayern.And in-demand Goretzka, whose contract expires at the end of the season, this week suggested he will make a decision over his future in January, with Manchester United reportedly in the race for his signature.”I have to find out for myself what the next step should be,” the 22-year-old said. “I have to consider a million things.”I am a person who is very meticulous in such decisions. I play through all the scenarios. So I need time.”There doesn’t exist a deadline, but I think we are in the final phase.”last_img read more